A tumor's cell lineages can change as it grows
As a tumor's cells divide, genetic changes can accumulate in different lineages. Researchers reconstruct earlier and later changes from tumor samples rather than watching every cell over a person's lifetime.
Questions you could explore
- What would distinguish a new mutation from an existing cell lineage becoming more common?
- How could treatment alter which tumor cell lineages survive and expand?
Start reading
- National Cancer InstituteMapping Cancer Genomic Evolution Offers Insights into Tumor Development
NCI explains a 2020 genomic study that inferred the order of changes across tumor samples.
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